resume

 

Curriculum Vitae


______ Kris A. Dines, Ph. D.____________________________________________________

   6124 North Chester Avenue, Indianapolis, Indiana 46220          (317) 255‑4535       kdines@gmail.com


Research Scientist


Electrical & Computer Software Engineer

Design & Development of Software and Computer-Controlled Systems


Professional Experience, Indianapolis, Indiana______________________________________

Senior Software Engineer

               Vision Solutions  www.visionsolutions.com , Sept. 2011-present

Chief Scientist and President

                XDATA Corporation    www.XdataRnD.com , 1979 - Present

Visiting Associate Professor, Electrical Engineering

Indiana University‑Purdue University at Indianapolis (IUPUI), 2002-2006

Consultant / Subcontractor

Focus Surgery, Inc., 1999-2006

Associate Professor, Electrical Engineering

Indiana University‑Purdue University at Indianapolis, 1990-1996

Adjunct Assistant Professor of Radiology, Volunteer

Indiana University School of Medicine, 1982-1989

Research Scientist

Indianapolis Center for Advanced Research, 1978-1988

Electronics Engineer, Electronics Engineering Department

Lawrence Livermore National Laboratory, Livermore, California, 1977‑1978

Top‑secret (Q) security clearance

Consultant

G. D. Searle, Inc., Chicago, Illinois, 1976


Areas of Expertise________________________________________________________________

●     Software Development               ●    Problem Solving                         ●     Hands-on Engineering

●     Academia                                   ●    Consulting                                  ●     Prototype Development

●     Interfacing with Clients              ●    Proposal Preparation                   ●     Patent Development

●     Business Management                ●    Team Leadership                        ●     Project Management


   Engineering

  ●Applied Research         ●   Theoretical and Experimental Development       ●   System Design

●Software implementation of applications, with emphasis on creating new software-driven systems,

      control of laboratory-based instrumentation, and design and development of prototype systems


  Research and Development

●Medical and geophysical applications, including transmission and reflection computed tomography,

      three-dimensional imaging, image‑guided surgery, ultrasound breast imaging and expert systems

●Served as reviewer on Government grant proposals and peer-reviewed journal publications


   Commercial Systems

●Three-dimensional ultrasonic imaging for breast cancer detection and image-guided ultrasonic prostate

surgery. Work emphasizes design of system architectures from a combined software/hardware

viewpoint, project management, and prototype development



                                                                            Kris A. Dines, Ph. D.   -   Page 1 of 14

Computer Programming

●Engineering programming in Fortran, C, C++, Java, C# and Matlab. Windows, UNIX, and Mac OS X

●Hands‑on scientific/engineering software development and design/control of computer‑driven systems

●VMware vSphere SDK, vCloud API, vCenter Server, ESXi, vCloud Director


   Teaching and Academic Experience

●Acting Chairman of the Department of Electrical and Computer Engineering, IUPUI, and 10 years of teaching courses in electrical engineering in the areas of probability, circuits, signals and systems, image processing, data structures, C programming, and senior design

●Served on various committees at the University, School, and Department levels

●Conducted interdisciplinary research with the Indiana University School of Medicine


Education____________________________________________________________________________

Purdue University, West Lafayette, Indiana

Ph. D., Electrical Engineering. GPA 6.00/6.00. 1976

M. S., Electrical Engineering. GPA 6.00/6.00. 1973

B. S., Electrical Engineering, Highest Distinction. GPA 5.93/6.00. 1972


Patents_______________________________________________________________________________

“Mammography Method and Apparatus” Kris A. Dines, Elizabeth Kelly-Fry, Ada Patricia Romilly. An

apparatus for 3D ultrasound breast imaging, used in conjunction with x-ray mammography, providing multi-modal, spatially-registered imaging for breast cancer detection. XDATA Corporation

●Patent No. US 6,574,499 B1, (Apparatus claims), June 3, 2003

●Patent No. US 6,876,879 B2, (Methods claims), April 5, 2005


Achievement Highlights_________________________________________________________

●Founded and currently manage successful consulting and contract company, XDATA Corporation

●Acted as principal investigator on 30 research and development projects for companies, universities, and the U. S. Government

●Authored or co‑authored 59 scholastic publications: journal articles, conferences, abstracts, poster sessions, exhibits, and technical reports

●Led team of three developers who designed and implemented software (Java and C) for commercial 3D imaging and image-guided prostate surgery machine

●Invented  “Mammography Method and Apparatus”

●Developed new imaging technologies: (1) computerized geophysical tomography; and (2) electrical conductivity imaging (with colleagues at Lawrence Livermore National Laboratory)


Awards_______________________________________________________________________________

Certificate of Merit: K. A. Dines, V. P. Jackson, L. W. Bassett, “A Computerized Expert System for Mammography,” Scientific Exhibit, 74th Scientific Assembly and Annual Meeting, Radiological Society of North America (RSNA), Chicago, IL, Nov. 27-Dec.2, 1988

Outstanding Professor: 2005-2006 Electrical and Computer Engineering outstanding teacher award (as voted by the students), School of Engineering and Technology, Indiana University-Purdue University Indianapolis (IUPUI)


Honors and Affiliations__________________________________________________________

●Emmet Blakeney Gleason Scholarship

●Tau Beta Pi (Engineering Honorary)

●Eta Kappa Nu (Electrical Engineering Honorary)

●Member, Institute of Electrical and Electronics Engineers (IEEE)

●Member, American Institute of Ultrasound in Medicine (AIUM)


                                              Kris A. Dines, Ph. D.   -   (317) 255-4535   -   Page 2 of 14


Journal Publications


1.  K. A. Dines and A. C. Kak: “Constrained Least Squares Filtering,” IEEE Trans. Acoustics,

     Speech, and Signal Processing, ASSP‑25(4):346‑350, August 1977.


2.  A. C. Kak and K. A. Dines: “Signal Processing of Broadband Pulsed Ultrasound: Measurement of

     Attenuation of Soft Biological Tissues,” IEEE Trans. Biomed. Engrg., BME‑25(4):321‑344, July

     1978.


3.  E. F. Laine, K. A. Dines, J. T. Okada and R. J. Lytle: “High Frequency Electromagnetic Probing to

     Characterize Seals in Cofferdams,” Proceedings of the American Society of Civil Engineers,

     Journal of the Geotechnical Engineering Division, August 1978.


4.  K. A. Dines and A. C. Kak: “Ultrasonic Attenuation Tomography of Soft Tissues,” Ultrasonic Imaging

     1(1):16‑33, January 1979.


5.  K. A. Dines and R. J. Lytle: “Computerized Geophysical Tomography,” Proc. IEEE: 1067‑1073, July

     1979. Also reprinted in: Imaging Technology (H. Lee and G. Wade Eds.), IEEE Press, ISBN 087942‑

     199‑1, 1986.


6.  S. A. Goss, L. A. Frizzell, F. Dunn and K. A. Dines: “Dependence of the Ultrasonic Properties of

     Biological Tissue on Constituent Proteins,” J. Acoust. Soc. Am. 67(3); 1041‑1050, March 1980.


7.  R. J. Lytle and K. A. Dines: “Iterative Ray Tracing Between Boreholes for Underground Image

     Reconstruction,” IEEE Trans. on Geoscience and Remote Sensing, GE‑18(3):234‑240, July 1980.


8.  K. A. Dines and R. J. Lytle: “Analysis of Electrical Conductivity Imaging,” Geophysics 46(7):1025‑1036,

     July 1981.


9.  K. A. Dines, F. J. Fry, J. T. Patrick, and R. L. Gilmor: “Computerized Ultrasound Tomography of

     the Human Head: Experimental Results,” Ultrasonic Imaging, 3:342‑351, 1981.


10.  F. J. Fry, N. T. Sanghvi, R. F. Morris, J. L. Clendenon, K. A. Dines, J. T. Patrick and S. A. Goss:

       “Ultrasonic Diagnostic System for Interactive Interrogation of Adult Brain Through Intact Skull,”

       Invest. Radiol. 17:463‑469, 1982.


11.  K. A. Dines, P. W. Sheets, J. A. Brink, C. W. Hanke, K. A. Condra, J. L. Clendenon, S. A. Goss, D. J.

       Smith, and T. D. Franklin, “High Frequency Ultrasonic Imaging of Skin: Experimental Results,”

       Ultrasonic Imaging 6: 408‑434, 1984.


12.  J. A. Brink, P. W. Sheets, K. A. Dines, M. R. Etchison, C. W. Hanke, and A. M. Sadove, “Quantitative

       Assessment of Burn Injury in Porcine Skin with High-Frequency Ultrasonic Imaging,” Investigative

       Radiology, 21(8), August 1986.


13.  K. A. Dines and S. A. Goss, “Computed Ultrasonic Reflection Tomography,” IEEE Trans. on UFFC,

       UFFC‑34(3), May 1987.


14.  F. J. Fry, K. A. Dines, C. R. Reilly, S. A. Goss, “Losses in Tissue Associated with Finite Amplitude

       Ultrasound Transmission,” Ultrasound in Med. and Biol., 15(5):481‑497, August 1989.



                                             Kris A. Dines, Ph. D.   -   (317) 255-4535   -   Page 3 of 14

15.  J. T. Patrick, M. N. Nolting, S. A. Goss, K. A. Dines, J. L. Clendenon, M. A. Rea, R. F. Heimburger,

       “Ultrasound and the Blood‑Brain Barrier,” Consensus on Hyperthermia for the 1990s, H. I. Bicher

       et al, eds., Plenum Press, New York, 1990.


16.  V. P. Jackson, K. A. Dines, L.W. Bassett, R. H. Gold, H. E. Reynolds, “Diagnostic Importance of the

       Radiographic Density of Noncalcified Breast Masses: Analysis of 91 Lesions,” American  Journal

       of Roentgenology, 157:25‑28, July 1991.


17.  F. J. Fry, C. R. Reilly, K. A. Dines, M. R. Etchison, E. J. Trauner, “Absorption in Liver at the Focus

       of an Ultrasonic Shock Wave Field,” Ultrasound in Med. & Biol., 17(1):65‑69, 1991.


18.  S. L. Myers, K. A. Dines, D. A. Brandt, K. D. Brandt, M. E. Albrecht, E. Wu, “Assessment by High

       Frequency Ultrasound of Articular Cartilage Thickness and Osteoarthritic Changes,” The Journal

       of Rheumatology, Toronto, Canada, vol. 22, pp. 109‑116, 1995.


19.  M. Penna, K. Dines, R. Seip, R. Carlson, N. Sanghvi, “Modeling Prostate Anatomy from Multiple View

       TRUS Images for Image-Guided HIFU Therapy,” IEEE Transactions on Ultrasonics, Ferroelectrics, and

       Frequency Control, 54 (1), January, 2007, p 52‑68.


20.  M. Penna and K. Dines, “A simple method for fitting sphere‑like surfaces,” IEEE Transactions on Pattern

       Analysis and Machine Intelligence, 29 (9), September, 2007, p 1673‑1678.



Conferences


1.  K. A. Dines, A. E. Weyman, T. D. Franklin, Jr., J. K. Cuddeback, N. T. Sanghvi, K. S. Avery, A. I. Baird

     and F. J. Fry: “Quantitation of Changes in Myocardial Fiber Bundle Spacing with Acute Infarction, Using

     Pulse‑Echo Ultrasound Signals,” Circulation 60(4):11‑17, 1979.


2.  K. A. Dines, F. J. Fry, J. T. Patrick and R. L. Gilmore: “Imaging the Human Head by Computerized

     Ultrasound Tomography,” presented at 26th Annual Meeting of AIUM, San Francisco, CA,

     Aug. 17‑21, 1981.


3.  N. T. Sanghvi, F. J. Fry, R. Morris, J. L. Clendenon, K. A. Dines, J. T. Patrick, J. E. Barger and

     J. Chatigny: “Systems Approach for Ultrasonic Transkull Visualization and Interrogation Device,”

     presented at 26th Annual Meeting of AIUM, San Francisco, CA, Aug. 17‑21, 1981.


4.  K. A. Dines and S. A. Goss, “Computed Ultrasonic Reflection Tomography,” Drexel Symposium

     on Computers in Ultrasound, Bryn Mawr, PA, Sept. 22‑ 24, 1985.


5.  J. T. Patrick, M. N. Nolting, S. A. Goss, K. A. Dines, J. L. Clendenon, M. A. Rea, R. F. Heimburger,

     “Focal Modification of the Blood‑Brain Barrier with High Intensity Ultrasound: Experimental Results and

     Potential Application for Brain Tumor Therapy,” American Federation for Clinical Research, Western

     Meeting, Carmel, CA, Feb. 3‑6, 1987.


6.  V. P. Jackson, K. A. Dines, L. W. Bassett, “A Computerized Expert System for Mammography,” works in

     progress, 74th Scientific Assembly and Annual Meeting, Radiological Society of North America, Chicago,

     IL, Nov. 27-Dec. 2, l988.




Kris A. Dines, Ph. D.   -   (317) 255-4535   -   Page 4 of 14


7.  J. A. Brink, K. A. Dines, J. T. Ferrucci, “Sectional Volumetric Sonography: Application for Gallstone

     Burden Quantification,” at the 75th Scientific Assembly and Annual Meeting, Radiological Society of North

     America, Chicago, IL, Nov. 26‑Dec. 1, l989.


8.  V. P. Jackson, K. A. Dines, L. W. Bassett, R. H. Gold, H. E. Reynolds, “The Role of Density in the

     Evaluation of Breast Masses,” presented at the ACR 24th National Conference on Breast Cancer, New

     Orleans, LA, Mar. 15‑18, 1990.


9.  K. Brandt, S. Myers, K. Dines, D. Brandt, “High-frequency Ultrasound Scans Characterize Normal (NAC)

     and Osteoartritis (OAC) Cartilage,” Osteoarthritis and Cartilage, 1(1):23‑24, Jan. 1993.


10.  S. Myers, K. Dines, M. Albrecht, D. Brandt, E. Wu, K. Brandt, “Assessment by High Frequency

       Ultrasound (HFU) of the Thickness and Subsurface Characteristics of Normal and Osteoarthritic Cartilage,”

       40th Annual Meeting, Orthopedic Research Society, New Orleans, LA, Feb. 21-24, 1994.


11.  K. A. Dines, P. Harper, A. C. Kak, “Ex: Expert Radiology Assistant for Breast Cancer Diagnosis,” The

       Workshop of Computer-aided Diagnosis in Medical Imaging, Georgetown University Medical Center,

       Washington, D.C., July 5‑6, 1994.


12.  K. A. Dines, P. Harper, A. C. Kak, “Ex: Expert System for Breast Cancer Diagnosis,” Proceedings

       of the International Conference on Computer Applications in Engineering and Medicine, pp. 83-88,

       ISBN: 1-880843-11-0, Editors: M. El-sharkawy, E. Berbari, University Place Hotel, Indianapolis, IN,

       Mar.15‑17, 1995.


13.  E. Kelly-Fry, K. A. Dines, A. P. Romilly-Harper, “Mammography Instrumentation for Combined X-ray and

       Ultrasound Imaging,” Ninth International Congress on the Ultrasonic Examination of the Breast,

       Indianapolis, IN, Sept. 28‑Oct. 1, 1995.


14.  K. A. Dines, E. Kelly-Fry, A. P. Romilly-Harper, “Automated Three-Dimensional Ultrasound Breast

       Scanning in the Craniocaudal Mammography Position,” Ninth International Congress on the Ultrasonic

       Examination of the Breast, Indianapolis, IN, Sept. 28‑Oct. 1, 1995.


15.  A. P. Romilly-Harper, E. Kelly-Fry, K. A. Dines, “Clinical Evaluation of Manual, Automated and 3‑D

       Ultrasound Imaging of Breasts Compressed in the Same Position Modes Applied in X-ray Mammography,”

       Ninth International Congress on the Ultrasonic Examination of the Breast, Indianapolis, IN,

       Sept. 28‑Oct. 1, 1995.


16.  A. P. Romilly-Harper, E. Kelly-Fry, K. A. Dines, “New Instrumentation Providing Compressed Breast

       Ultrasound Images that Correlate Directly with X-ray Mammography Images: Clinical Evaluation,”

       Eighteenth Annual San Antonio Breast Cancer Symposium, San Antonio, TX, Dec.10‑13, 1995.


17.  K. A. Dines, E. Kelly-Fry, A. P. Romilly-Harper, “Automated Three-Dimensional Ultrasound Breast

       Scanning in the Compressed Mammography Position,” American Institute of Ultrasound in Medicine’s 43rd

          Annual Convention, San Antonio, TX, Mar. 14‑17, 1999.








Kris A. Dines, Ph. D.   -   (317) 255-4535   -   Page 5 of 14



PUBLICATIONS with FOCUS SURGERY, INC.


Proceedings Papers


1.  R. Seip, J. Tavakkoli, K. Dines, A. Wunderlich, N. T. Sanghvi, and L. A. Crum, “Real-time Detection

     of Multiple Lesions during High Intensity Focused Ultrasound (HIFU) Treatments,” Proceedings of the

     International Symposium on Therapeutic Ultrasound, 2002, pp. 168‑175.


2.  R. Seip, J. Tavakkoli, R. Carlson, A. Wunderlich, N. Sanghvi, K. Dines, and T. Gardner, “High-Intensity

     Focused Ultrasound (HIFU) Multiple Lesion Imaging: Comparison of Detection Algorithms for Real-Time

     Treatment Control,” IEEE Ultrasonics Symposium Proceedings, 2002, pp. 1395‑1398.


3.  R. Seip, R. F. Carlson, W. Chen, K. A. Dines, M. A. Penna, R. Pfile, and N. T. Sanghvi, “Automated

     HIFU Treatment Planning and Execution based on 3D Modeling of the Prostate, Urethra, and Rectal

     Wall,” IEEE Ultrasonics Symposium Proceedings, 2004, pp. 1781‑1784.


4.  W. Chen, R. F. Carlson, R. Seip, N. T. Sanghvi, K. A. Dines, R. Pfile, M. A. Penna, and T. A. Gardner,

     “The Detection and Exclusion of Prostate Neuro-Vascular Bundles (NVB) in Automated HIFU

     Treatment Planning using a Pulsed-Wave Doppler Ultrasound System,” Proceedings of the International

     Symposium on Therapeutic Ultrasound, 2004, pp. 23‑26.


5.  R. Fedewa, R. Seip, R. F. Carlson, W. Chen, N. T. Sanghvi, K. A. Dines, M. A. Penna, and Richard

     Pfile, “Automatic Treatment Planning for Prostate HIFU Therapy,” to appear in the IEEE Ultrasonics

     Symposium Proceedings, 2005.


Abstracts


1.  N. Snaghvi, R. Carlson, R. Seip, J. Tavakkoli, K. Dines, T. Gardner, and T. Uchida, “SonablateTM500: A

     novel ultrasound platform for transrectal image-guided treatment of prostate diseases,” J. Acousti. Soc. Am.,

     Vol. 110, No. 5, Pt. 2, Nov. 2001, pp. 2644 (142nd Meeting).


2.  N. Sanghvi, A. Wunderlich, J. Tavakkoli, L. Crum, and K. Dines, “Quantitative Imaging During Tissue

     Treatment Using High Intensity Focused Ultrasound (HIFU),” American Institute of Ultrasound in Medicine

     (AIUM), Mar. 2002.


3.  R. Seip, N. Sanghvi, R. Carlson, J. Tavakkoli, K. Dines, T. Gardner, and T. Uchida, “Sonablate 500: A

     Novel Platform for Transrectal Image-Guided HIFU Treatment of Localized Prostate Cancer,” 32nd Annual

     Ultrasonic Industry Association (UIA) Symposium, Oct. 2002, New York, NY.


4.  N. Sanghvi, A. Wunderlich, R. Seip, J. Tavakkoli, K. Dines, M. Bailey, and L. Crum, “Detection Theory

     applied to High-Intensity Focused Ultrasound (HIFU) Treatment Evaluation,” 145th Meeting of the

     Acoustical Society of America, Apr./May 2003, Nashville, TN.



POSTER SESSIONS AND EXHIBITS


1.  H. Y. Yune, E. W. Olson, K. A. Dines, E. C. Klatte: “Determination of Relative Flow Rate on Renal Digital

     Subtraction Angiography (Technical Considerations),” presented at 84th Annual Meeting of the Roentgen

     Ray Society, Las Vegas, NV, Apr. 8‑13, 1984.


                                               Kris A. Dines, Ph. D.   -   (317) 255-4535   -   Page 6 of 14


2.  K. A. Dines: “Computed Reflection Tomography for Underground Imaging,” presented at International

     Symposium on Observation of the Continental Crust Through Drilling, Tarrytown, NY, May 20‑25, 1984.


3.  K. A. Dines, V. P. Jackson, L. W. Bassett, “A Computerized Expert System for Mammography” Scientific

     Exhibit, 74th Scientific Assembly and Annual Meeting, Radiological Society of North America, Chicago, IL,

     Nov. 27‑ Dec.2, 1988. Certificate of Merit Award.


4.  J. A. Brink, K. A. Dines, J. T. Ferrucci, “Sectional Volumetric Sonography: Application to Quantification of

     Gallstone Burden” Exhibit, Third International Symposium for Biliary Lithotrypsy, Munich, FRG,

     Sept. 13-15, 1990.


5.  V. P. Jackson, K. A. Dines, M. R. Wild, E. C. Klatte, “Computer-Assisted Mammography Instruction”

     Education Exhibit (InfoRAD), 76th Scientific Assembly and Annual Meeting, Radiological Society of North

     America, Chicago, IL, Nov. 25‑Nov. 30, 1990.


6.  S. L. Myers, K. A. Dines, K. D. Brandt, “Ultrasound Studies of Normal and Osteoarthritic Articular

     Cartilage,” poster session, Central Region Meeting ACR, Chicago, IL, Jan. 1992.


7.  K. A. Dines, P. Wendt, J. Clendenon, R. Safavian, “Fractal Texture Measures in Medical Ultrasound,”

     Symposium on Nonlinear Systems in Medicine & Biology, Indianapolis IN, May 11‑12, 1994.


8.  K. A. Dines, P. Wendt, J. Clendenon, R. Safavian, “Generation and Dimensional Measurement of Fractal

     Signals,” Symposium on Nonlinear Systems in Medicine & Biology, Indianapolis IN, May 11‑12, 1994.



REPORTS


1.  K. A. Dines and A. C. Kak: “Measurement and Reconstruction of Ultrasonic Parameters for Diagnostic

     Imaging,” Purdue University Research Report, TR‑EE 77‑4, Dec. 1976.


2.  K. A. Dines and R. J. Lytle: “Iterative Reconstruction of Underground Refractive Index Distributions from

     Cross-Borehole Transmission Data,” Lawrence Livermore Laboratory Report UCRL‑52348 (available from

     National Technical Information Service, Springfield, VA), 1977.


3.  R. J. Lytle and K. A. Dines, E. F. Laine and D. L. Lager: “Electromagnetic Cross‑Borehole Survey of a Site

     Proposed for a Future Urban Transit Station,” Lawrence Livermore Laboratory Report UCRL-52413, 1978.


4.  R. J. Lytle and K. A. Dines: “An Impedance Camera: A System for Determining the Spatial Variation of

     Electrical Conductivity,” Lawrence Livermore Laboratory Report UCRL-52413, 1978.


5.  S. L. Myers, K. A. Dines, K. D. Brandt: “In Vitro Ultrasound Studies of Articular Cartilage,” Ciba-Geigy

     Corp., Sept. 1992.


6.  R. F. Carlson, J. Tavakkoli, K. A. Dines, Sonablate 500 software technical manual, P/N 110-01000-0002,

     Version 1.0, Focus Surgery Inc., Indianapolis, IN, Apr. 2001.







Kris A. Dines, Ph. D.   -   (317) 255-4535   -   Page 7 of 14


Appendix A


Research and Development Projects as Principal Investigator

XDATA Corporation


Electromagnetic Probing of Tar Sands

Cities Service Oil Co.

Field experiment on microwave transmission in deep tar sands and tomographic reconstruction of

attenuation between boreholes for energy recovery monitoring, Athabasca region of Alberta Canada, (1980).


Reflection Tomography for Underground Imaging

Lawrence Livermore National Laboratory

Digital reconstruction technique developed, implemented, and tested by computer simulation in order to assess the feasibility of imaging the acoustic reflectivity in underground cross sections using backscattered energy obtained by fan-beam and linear-array pulse-echo probing from the earth's surface and from boreholes (1981‑1984).


Computerized Underground Image Reconstruction

U.S. Department of Energy

Software development (Fortran) for a field-deployable, microcomputer‑based geotomographic imaging system.  Theory and software for transmission computed microwave tomography applied to cross-borehole scanning.  Theory and software for electrical conductivity imaging.  DEC LSI 11/23 computer using RSX‑11M operating system (1982‑1985).


Computed Ultrasonic Reflection Tomography: Phase I

National Institutes of Health (NCI)

Feasibility studies for the development of ultrasonic reflection tomography applied to breast imaging.  Theory, software and in vitro experiments (1983‑1984).


Reflection Tomography Experiments

Labsonics, Inc. Mooresville, IN

In vitro experiments using techniques developed under NIH funding to demonstrate the potential of reflection tomography for imaging calcifications in the breast (1984).


Coordinate Transforms for Brain Lesioning

Technical Development Corp., Mooresville, IN

Theory and software for relating X-ray CT scans and stereotactic head holder to an ultrasonic brain lesioning system for guidance of an ultrasound beam to lesioning sites (image‑guided surgery) (1984‑1986).


Computed Ultrasonic Reflection Tomography: Phase II

National Institutes of Health (NCI)

Development of reflection tomography for in vitro and in vivo breast scanning, including a prototype system for breast scanning in the prone position (1985-1989).


Lateral Filtering for B‑Mode Ultrasound

Indianapolis Center for Advanced Research/CST

Development of theory and software for digital filtering of B‑mode ultrasound images to enhance lateral resolution.  Performance of experiments to verify methodology (1985).



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Expert Radiology Assistant: Image Enhancement

Indiana University Department of Radiology

Digital enhancement of X-ray mammograms (1987).


Ultrasonic Imaging for Hyperthermia Therapy Planning

Labeco‑CST and Labthermics Technologies, Inc.

Development of a three‑dimensional ultrasound imaging system for visualization of the treatment volume at therapeutic resolution utilizing a mechanical robotic arm, linear ultrasonic array, and free‑hand scanning. (1987‑1992).


Expert Radiology Assistant: Phase I

National Institutes of Health (NCI)

Development of a prototype rule‑based expert system for mammography (1987‑1988).


Iterative Ray Tracing for Underground Imaging

Lawrence Livermore National Laboratory

Conversion and modifications to software developed in earlier work for reconstruction of refractive index images from time‑of‑flight transmission data obtained via cross‑borehole electromagnetic probing (1987).


High Resolution Ultrasound

Indianapolis Center for Advanced Research

Development of software for ultrasound image display and analysis (1988‑1989).


Fractal Texture Measures in Medical Ultrasound

National Institutes of Health (NCI)

SBIR Phase I study on the application of fractal geometry to ultrasonic tissue characterization (1988‑1989).


Objective Analysis of Breast Masses

Indiana University Radiology Associates

Digital analysis and pattern classification of breast masses for assessment of the diagnostic significance of density (1989).


Computer‑Aided Mammography Instruction

Indiana University Radiology Associates

Hypercard based system for demonstration of the appearance of breast abnormalities in X-ray mammograms using Apple Macintosh computer (1990).


Expert Radiology Assistant: Phase II

National Institutes of Health (NCI)

Development of a probabilistic expert system for diagnosis of breast cancer from X-ray and ultrasound image features and patient symptoms. The system is implemented in C++ as an expert system shell with expertise entered via files and interactively through a graphical interface using the OpenLook GUI on a Sparc workstation.  Information‑theoretic machine induction is employed to assess the relative importance of features and determine the minimal rule set for diagnosis (1991‑1993).


Ultrasonic Volume Imaging Software

Acuson, Inc.

Software to reconstruct and display volume ultrasonic images from arbitrarily oriented 2‑d image planes, running on a Sun Sparc, implemented in C++. Volume reconstruction, 3d rendering, and orthogonal slice display. (1993).


Kris A. Dines, Ph. D.   -   (317) 255-4535   -   Page 9 of 14

Combined X-ray and Ultrasound Mammography

Indinapolis Breast Center

Feasibility research and development of automated 3d ultrasound breast scanning applied in combination with X-ray mammography (1994‑1995).


Ultrasound Dense Tissue Machine/Adjunct to Mammography

National Institutes of Health / Indianapolis Breast Center

Development of an automated three-dimensional ultrasonic scanner to image the breast and correlation of findings with X-ray mammography. Computer-controlled scanning and image reconstruction using digitized B-Mode images obtained with patient in the X-ray mammography position. Performed system design, fabrication, and computer programming, to develop a clinical prototype apparatus.  Resulted in a patent application. (1996‑1998).


Automated 3D Ultrasound Scanner for Image-Guided Hyperthermia of Breast

NIH and Labthermics Technologies, Inc.

Developed a modified prototype of the 3d ultrasound breast scanner, described above, configured for the hyperthermia application (1998‑1999).


Ultrasound Signal Processing for Assessment of Bone Density

Lunar Corporation

Research and development of signal processing techniques for ultrasonic imaging and quantification of bone density using through-transmission ultrasound signals (1999).


Image-Guided Ultrasound Surgery Device Development

Focus Surgery, Inc.

Software project management, design, and development of software (Java, C++, Windows NT) for ultrasound imaging and image‑guidance for high‑intensity focused ultrasound (HIFU) treatment of prostate disease.  Development of a commercial instrument: SB500 (1999‑2000).


3D Image‑Guidance for Prostate Cancer Therapy

NIH and Focus Surgery, Inc.

Development of advanced 3D ultrasonic imaging techniques and software for application to image‑guided prostate cancer treatment (2000‑2001, 2003‑present).


Rule‑Based Interpreter for Business Logic Processing

ReMember Data Services, Inc., (Consultant)

Research and evaluation of commercially available rule-based systems for use within the Java framework.  Recommendation of approaches and rule architectures. Development of a prototype rule-engine in Java for forward-chaining rule-based banking software. A prototype English-like rule language was defined and a translator was developed to generate Java code for dynamic loading into the system. (Oct. 2000 ‑ Aug. 2001).


Feedback Signal Processing Software Development for Lesion Imaging

NIH and Focus Surgery, Inc.

Research, development, and implementation, in Java, of signal processing and image overlays for quantification, visualization, and control of lesion formation during HIFU prostate treatment (2001‑2002).


Computed Ultrasonic Imaging Methods and Thermoacoustic Tomography

Optosonics, Inc.

Literature search and analysis aimed toward incorporating computerized reflection ultrasound imaging into a prototype thermo-acoustic breast scanner (2001).


Kris A. Dines, Ph. D.   -   (317) 255-4535   -   Page 10 of 14


Ultrasound Imaging and Therapy for Prostate Cancer

NIH and Focus Surgery, Inc.

Research, development, and implementation, in Java and Matlab, of interactive boundary tracing, three-dimensional surface modeling, and automatic treatment planning, based upon ultrasound images, for prostate cancer therapy. (2003‑2005).


Robotic High Intensity Focused Ultrasound (HIFU) Manipulator System for Critical Systems Transport (CSTAT)

U.S. Army Medical Research & Material Command (USAMRMC) and Focus Surgery, Inc.

Phase 1 & 2 STTR feasibility study of image‑guided ultrasonic wound cauterization system for battlefield use. (2005‑2008).


Automated 3D Breast Ultrasound System Upgrade and Testing (MammoSonic3D)

Hologic, Inc.

Upgrade the Xdata breast scanner, as implemented according to the claims in patents, 6,574,499 B1 and 6,876,879 B2, with new software and hardware to assess image quality and test it on human subjects to determine the potential for commercialization. (2007‑2011).




Appendix B


Details of University Experience

Indiana University-Purdue University, Indianapolis (IUPUI)


Grants and Contracts


“Ultrasonic Scanning of Cartilage,” Ciba-Geigy Corp., 1/1/91‑6/30/91, $30,000.


“Acoustic Microscopy,” Showalter Residuary Trust, 7/1/91‑6/30/92, $274,680.


“Ultrasonic Characterization of Articular Cartilage,” National Institutes of Health, 12/1/91‑11/30/94, $129,051.


“Utility of High Frequency Ultrasound in Assessing Changes in Articular Cartilage and Subcondral Bone in Osteoarthritis,” Proctor & Gamble Company, Stephen Myers, M.D., Principal Investigator, $91,684. Electrical Engineering component, Dines, $8,010 + indirect, project duration 2/1/94‑6/30/95.


“Institute for Forensic Imaging,” initiative to develop a University Center or Institute for application of computer-aided imaging to law enforcement, responsible for helping to develop business plan and research agenda (1995‑1996).


“Mathematics of Digital Image Processing,” proposal for development of a course & laboratory in collaboration with the Department of Mathematics to provide applications experience to math majors. Part of University-wide proposal submitted to NSF (Feb. 1995).








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Teaching Experience


1990‑2006  Associate Professor of Electrical Engineering (IUPUI)


2002‑2006  Visiting Assoc. Prof, Electrical and Computer Engineering (IUPUI)


1975‑1976  Graduate teaching assistant in EE301 for undergraduate independent study

             School of Electrical Engineering, Purdue University, West Lafayette, IN



Courses Taught (IUPUI)

Department of Electrical Engineering (later renamed to Electrical and Computer Engineering)


EE 195 Introduction to C Programming for Electrical Engineers

ECE 201 Linear Circuit Analysis

ECE 264 Advanced C Programming

ECE 301 Signals & Systems

ECE 302 Probabilistic Methods in Electrical Engineering

ECE 359 Data Structures (using C)

ECE 492 Senior Design

EE 495/595 Digital Image Processing in Medicine: Senior & Graduate level (developed the course).

ECE 595 Digital Image Processing in Medicine Graduate level only)



Graduate Students


1991  Mike Anderson, MSEE (chairperson), Rosario Ramirez, MSEE


1992  Mike Anderson, MSEE (chairperson), Billy Stephens, MSEE, Sarvani Vemullapali, MSEE


1993  Mike Anderson, MSEE (chairperson), graduated May 1993, Jon Burgoyne/MSEE, Anurag Bansal,

          MSEE, Seyid Mir Mahdavi/MSEE, Daya Manatunga, MSEE Kwan Woo Lee, MSEE


1994  Jon Burgoyne, MSEE, Anurag Bansal, MSEE, Seyid Mir Mahdavi, MSEE, Michelle Harding, MSEE

          David Hollinberger, MSEE


Undergraduate Students


1994  Senior Design Group (EE 492), “Computer Analysis of Breast Masses”

          Ana Merkel, Kyujin Kim, Max Belotserkovsky, Newton Guillen


2004  Senior Design Group (ECE 492), “Ultrasound Ringing Simulation”

          Madhulika Jha and Bonnie‑Lecona‑Perry


2006  Senior Design Group (ECE 492), “Color Doppler Ultrasound Image Analysis”

          Brian Deckard, Jordan Miller, Juan Bautista






                                                            Kris A. Dines, Ph. D.   -   (317) 255-4535   -   Page 12 of 14

Department Service


1990  Chairman, Bulletin Committee, revise EE portion

          Member, Search & Screen Committee for new faculty

          Student counseling


1991  Member, ABET Committee

          Member, Search & Screen Committee for new faculty

          Member, Search & Screen committee for EE chairman


1992  Member, EE Graduate Committee

          Member, ABET Committee

          Member, Search & Screen Committee for new faculty

          Member, Search & Screen Committee for EE chairman


1993  Member, EE Graduate Committee

          Member, Machine Intelligence Research Group Steering Committee

          Acting Chairman, Department of Electrical Engineering, July 1, 1993-Dec. 31, 1993,

              Internal proposal to Research Investment Fund of IUPUI, submitted fall 1993 (funded at

              approximately $14,000 for graduate student support)


1994  Acting Chairman, Department of Electrical Engineering, Jan. 1, 1994-June 30, 1994



School Service


1990  Presentation to EE490 Senior Seminar, “Tomography”

          Presentation to IUPUI Machine Intelligence Research Group (MIRG), “Expert Radiology

          Assistant”


1991  Presentation to IEEE Student Chapter, “Ultrasonic Reflection Tomography”


1992  Presentation to Dean’s Industrial Advisory Committee, “Computer Aided Imaging”

          Member, Faculty Development Awards Committee


1993  Member, Dean’s Senior Management Team.

          Member, Visions, Values, Mission & Goals—Strategic Plan Committee

          Engineering Liaison to Technology Transfer Group

          Co-Chair, Engineering & Technology Working Committee for development of new MBE (Medical

              and Biological Engineering) program


1994  Member, Dean’s Senior Management Team.

          Member, Visions, Values, Mission & Goals—Strategic Plan Committee

          Engineering Liaison to Technology Transfer Group

           Co-Chair, Engineering & Technology Working Committee for development of new MBE (Medical

             and Biological Engineering) program

          Member, Search & Screen for Director of Medical & Biological Engineering

          Member, Constitution & Bylaws Committee




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University Service


1990  Developed initial plan for Interdisciplinary Medical Imaging Laboratory for Department of Radiology


1991  Member, Medical Imaging Research Discussion Group

          Member, Indianapolis Center For Advanced Research Advisory Committee (ex-officio)


1992  Member, Search & Screen Committee for Dean of School of Engineering and Technology

          Presentation to Department of Physiology Imaging in Biology Seminar, “Computerized

          Reflection Tomography”


1993  Member, Search & Screen Committee for Dean of School of Engineering and Technology








































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